Results from a case series of patients with hidradenitis suppurativa using adalimumab during the COVID-19 pandemic in Salvador, Bahia, Brazil

Authors

DOI:

https://doi.org/10.18226/25253824.v6.n11.06

Keywords:

Hidradenitis suppurativa, Adalimumab, Covid-19

Abstract

Introduction: Hidradenitis suppurativa (HS) is a skin inflammatory disease of great impact on patients’ life quality, with Adalimumab being one of the main treatments available. However, little is known about the safety of its use during the COVID-19 pandemic. Objectives: To describe the frequency of symptoms related to COVID-19 in patients treated for HS with Adalimumab, adherence to prevention and hygiene measures, and the impact of HS on quality of life through the Dermatology Life Quality Index (DLQI). Methods: This paper is a prospective case series with six patients treated at HUPES-UFBA with Adalimumab. Biweekly telephone interviews were carried out to obtain demographic data and the occurrence of symptoms related to COVID-19, during the use of Adalimumab, adherence to preventive measures against the coronavirus and the DLQI score in the first and last interview, being a DLQI score bigger than 10 considered as disease’s great life impact. Results: Six patients agreed in participate. The main complaints possibly linked to COVID-19 were respiratory (24.6 %) and musculoskeletal (23.3 %); tachycardia (28.0 %) was the main symptom related to Adalimumab use. DLQI initial median was 16 (3-28), and its decrease varied among participants (5.6 % - 100.0 %). It was also seen a good adhesion to preventive measures against COVID-19, but one death COVID-related e 1 loss of follow-up happened. Conclusions: The Adalimumab is an anti-TNF immunobiological, and is associated with greater risk of infections on general population. The dosage used on HS treatment is greater than in other diseases like psoriasis and rheumatoid arthritis. On this study, besides the adhesion to preventive measures and DLQI increase, the COVID-related death and loss of follow-up represents a warning about the drug security, especially in non-vaccinated patients. Bigger studies are needed to affirm causality relation.

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Published

2022-06-18

How to Cite

Estrela Morbeck, C. A., Ribeiro Daltro, L., & Pedreira de Almeida Rêgo, V. R. (2022). Results from a case series of patients with hidradenitis suppurativa using adalimumab during the COVID-19 pandemic in Salvador, Bahia, Brazil. Interdisciplinary Journal of Applied Science, 6(11), 46–51. https://doi.org/10.18226/25253824.v6.n11.06