Biological aspects of Head and Neck Cancer

Authors

DOI:

https://doi.org/10.18226/25253824.v7.n12.01

Keywords:

Cancer, Head and Neck Cancer, Gene expression

Abstract

Cancers are genetic origin pathologies, caused by cell cycle anomalies, with two main groups of genes related to their development: Oncogenes and tumor suppressor genes. Head and neck cancer is the name given to a heterogeneous group of cancers that occur above the collarbone region. These pathologies are aggressive and disfiguring, with a high mortality rate due to late diagnosis. Many risk factors are associated with development of this pathology, being smoker, alcoholism and HPV infection the main. The last one, is so important, that oropharyngeal cancer received a new staging classification for patients HPV-postive and patients HPV-negative. It’s understood that earlier the cancer is diagnosed, better is the cure chance.  For that reason, more studies in this area are important.

References

World Health Organization (WHO). (2021). Cancer facts Sheets. Retirado de: https://gco.iarc.fr/today/fact-sheets-cancers

Reis, J. B., Oliveira, J. M., Nascimento, V. F., Cabral, J. F., Lucietto, G. C. & Rondinele, A. (2018). Câncer de Cabeça e pescoço: A comunicação e seus significados. Revista de Enfermagem UFPE. https://doi.org/10.5205/1981-8963-v12i12a237730p3263-3270-2018

Alberts, B., Johson, A., Lewis, J. Morgan, D. Raff, M. Roberts, K. Walter, P. Wilson, J. & Hunt, T. (2017a). Biologia Molecular da Célula. Tradução: Andrade, A. E. B. et al. 6.ed. Porto Alegre: Artmed.

Griffiths, A. J. F., Wessler, S. R., Caroll, S. B. & Doebley, J. (2019). Introdução a genética. Tradução: Sylvia Werdmüller von Elgg Roberto. 2.ed. Rio de Janeiro: Guamabarra Koogan.

Snustad, D. P. & Simmons, M. J. (2020). Fundamentos de genética. 7.ed. Rio de Janeiro: Guanabara Koogan.

Garcia, S. M. L. &Fernández, C. G. (2012). Embriologia. 3. Ed. Porto Alegre: Artmed.

Dias, M. S. & Maluf, S. W. (2011). Ciclo Celular. IN: Weidner S. et al. Citogenética humana. Porto Alegre: Artmed.

Alberts, B. (2017b). Fundamentos da biologia celular. Tradução: Andrade, A. E. B. et al. 4.ed. Porto Alegre: Artmed.

Kanapathipillai, M. (2018). Treating p53 Mutant Aggregation-Associated Cancer. Cancers (Basel). https://doi.org/10.3390/cancers10060154

Meek, D. W. (2015). Regulation of the p53 response and its relationship to cancer. Biochen J. https://doi.org/10.1042/bj20150517

Iwakuma, T. & Parrales, A. (2015). Targeting oncogenic mutant p53 for câncer therapy. Front oncol. https://doi.org/10.3389/fonc.2015.00288

Pierce, B. A. (2017). Genética: um enfoque conceitual. Tradução: Rosário, B. A. 5.ed. Rio de Janeiro: Guanabara Koogan.

Rodrigues, A. B. (2016). Oncogênese. IN: ORG: Rodrigues, A. B.; Martin, L. G. R. & Moraes, M. W. Oncologia Multiprofissional: Bases para assistência. Barueri, SP: Manoele.

Delves, P. J., Martin, S. J., Burton, D. R. & Roitt, I. M. (2018). ROITT – Fundamentos de imunologia. Tradução: Vouex, P. L. Rio de Janeiro: Guanabara Koogan.

Chow, L. Q. M. (2020). Head and Neck Cancer. The New England Journal of Medicine. http://doi.org/10.1056/NEJMra1715715

Konings, H., Stappers, S., Geens, M., Winter, B. Y., Lamote, K., Meerbeeck, J. P., Specenier, P., Vanderveken, O. M. & Ledeganck, K. J. (2020). A literature review of the potential diagnostic biomarkers of Head and Neck Neoplasms. Frontiers in oncology. v.10. https://dx.doi.org/10.3389%2Ffonc.2020.01020

Arquette, (2002). Câncer de Cabeça e Pescoço. IN: ORG: Ramaswamy, G. (2002). Washington – Manual de Oncologia. 1.ed. Rio de Janeiro: Editora Guanabara Koogan S.A.

Galbiatti, A. L. S., Padovani-junior, J. A., Maníglia, J. V., Rodrigues, C. D. S., Pavarino, E. C. & Goloni-Bertollo, E. M. (2013). Head and Neck Cancer: Causes, prevention and tratment. Brazilian Journal of Otorhinolaryngology. v. 79. p. 239-247. https://doi.org/10.5935/1808-8694.20130041

Johnson, D. E., Burtness, B., Leemans, C. R., Lui, V. W. Y., Bauman, J. E. & Grandis, J. R. (2020). Head and Neck squamous cell carcinoma. Nature reviews. https://doi.org/10.1038/s41572-020-00224-3

Harden, M. E. & Munger, K. (2017). Human Papillomavirus molecular biology. Mutation research. Reviews in mutation research. v. 772. https://doi.org/10.1016/j.mrrev.2016.07.002

Romanos, M. T. V. & Mendes, G. S. (2021). Viroses Oncogênicas. IN: ORG: Santos, N. S. O. et al (2021). Virologia Humana. 2021.

BRASIL (2021). Calendário Nacional de Vacinação. Retirado de: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/c/calendario-de-vacinacao

Brierley, J. et al. (2017). TNM Classification of Malignant Tumors. 8.ed.

Genden, E. M. (2020). Head and nec cancer: management and reconstruction. New York: Thieme. 2.ed.

Published

2023-05-16

How to Cite

Souza de Oliveira, N., & Rech, N. (2023). Biological aspects of Head and Neck Cancer. Interdisciplinary Journal of Applied Science, 7(12). https://doi.org/10.18226/25253824.v7.n12.01